Ophthalmology Research Today is a free monthly online journal that collates and summarizes the latest research about Ophthalmology, including details on eye surgery, myopia, cataracts.

Application of MEMS technology and engineering in medicine: a new paradigm for facial muscle reanimation.

Cockerham K, Aro S, Liu W, Pantchenko O, Olmos A, Oehlberg M, Sivaprakasam M, Crow L

Clinical Associate Professor, Department of Ophthalmology, Stanford University, Stanford, CA 94305, USA. kpcorb@aol.com , Research Associate, Palo Alto Institute for Research and Education, Palo Alto, CA 94304, USA. seppoaro@gmail.com , Professor, Department of Electrical Engineering, University of California, Santa Cruz, CA 95064, USA. wentai@soe.ucsc.edu , Graduate Student, Department of Electrical Engineering, University of California, Santa Cruz, CA 95064, USA. oxanchik@gmail.com , Medical Student, School of Medicine, University of California, San Francisco, CA 94143, USA. andreal.olmos@ucsf.edu , Graduate Student, Department of Electrical Engineering, University of California, Santa Cruz, CA 95064, USA. oehlberg@soe.ucsc.edu , Postdoctoral Researcher, Department of Electrical Engineering, University of California, Santa Cruz, CA 95064, USA. mohan@soe.ucsc.edu , Medical Student, School of Medicine, University of California, San Francisco, CA 94143, USA. lcrow1031@aol.com.

Translational research may lead to development of micro-electromechanical system-based devices to treat muscle and nerve dysfunctions whose current treatments are inadequate and, at best, palliative. This paper discusses the development of engineered microsystems as a treatment option for palsies of the seventh cranial nerve and the potential application of these devices as a platform technology for treatment of other nervous dysfunctions. The engineering techniques for electrical and chemical stimulation of denervated muscle are discussed along with current caveats from clinical and engineering standpoints. As opposed to current treatments, miniaturized implants offer the possibility of the reduced toxicity and increased specificity of direct drug delivery. As with the increased miniaturization of other technologies, engineering of these increasingly small implantable microsystems holds great promise for the future development of yet smaller, even nanoscale, implantable devices.

Published 2 May 2008 in Expert Rev Med Devices, 5(3): 371-381.
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