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Noninvasive identification of different intraocular lenses using Raman spectroscopy in porcine eyes.

Hwang JU, Choi H, Jeong DH, Kim MJ, Tchah H

Department of Ophthalmology, University of Ulsan College of Medicine, Asan Medical Center, Songpa-Gu, Seoul, Korea.

PURPOSE: To develop a noninvasive technique for identifying the specific type of intraocular lens (IOL) implanted in porcine eyes. SETTING: Department of Ophthalmology, University of Ulsan College of Medicine, Asan Medical Center, and Department of Chemistry Education, Seoul National University, Seoul, Korea. METHODS: A confocal Raman spectroscopy system was used to identify various acrylic (AcrySof SA60AT [Alcon], Sensar AR40e [Advanced Medical Optics], I-Flex [I-Medical Intraocular Lenses]) and silicone (ClariFlex, [Advanced Medical Optics]) IOLs implanted in enucleated pig eyes. Confocal Raman spectra of IOLs were obtained by photoexcitation using the 514.5 nm line from an argon-ion laser, with a power of 1 mW at the sample and an acquisition time of 10 to 100 seconds. RESULTS: All IOLs, including those composed of acrylic optic material from different manufacturers, exhibited distinct spectral peaks before and after implantation in pig eyes. CONCLUSION: Confocal Raman spectroscopy may represent a novel method for obtaining specific information about implanted IOLs through direct and noninvasive confocal observation of spectral characteristics.

Published 2 April 2007 in J Cataract Refract Surg, 33(4): 709-12.
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